Researchers showed Oral administration of low daily doses of Viagra in mice may reduce the risk of colorectal cancers.
Viagra is a medication; used commonly for treatment of erectile dysfunction and pulmonary arterial hypertension. It contains Sildenafil. Sildenafil acts by inhibiting enzyme phosphodiesterase-5 (PDE 5) which is responsible for breakdown of cyclic GMP and increases cyclic GMP levels. Cyclic GMP is involved in maintaining intestinal epithelial homeostasis.
Inflammatory bowel disease (IBD) ranks as the third highest risk condition for colorectal cancer behind only to genetically predisposed conditions familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer syndrome.
How Viagra (Sildenafil) benefits in colorectal cancer in mice?
Study findings encourage future human studies for use of Viagra in the prevention of colitis-driven colon cancer.
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